The station is located just a few minutes' walk from a rural village in Saronno known as Cascina Colombara, and from an industrial area. It is directly connected with the 527 Bustese provincial road.
The station was opened in 1991, at the same time as the quadruplication of the line; it was built in an outlying area as a rail-road interchange point, making it possible to reduce congestion around Saronno station in the city centre.
Between 2010 and 2012, redevelopment work was carried out on the Saronno-Seregno railway which also included the facility of Saronno Sud.
Modification of the railway line involved moving the route towards the south, and therefore away from homes, and rebuilding it in a cutting. It was decided to run it under Saronno Sud, and therefore a new two-track underground yard was built, so that it could also be used for the passenger service of the rebuilt line.
After completion of the work, on 9 December 2012 the stop also began to be served by the S9 using the new line.